▪ Abstract Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …

Correct expression of the genetic code at translation is directly correlated with tRNA identity.
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …

Abstract The Sex-lethal (Sxl) protein of Drosophila melanogaster regulates alternative
splicing of the transformer (tra) messenger RNA precursor by binding to the tra …

E. coli threonyl-tRNA synthetase (ThrRS) is a class II enzyme that represses the translation
of its own mRNA. We report the crystal structure at 2.9 Å resolution of the complex between …

Aminoacyl-tRNA synthetases (aaRS) ensure the faithful transmission of genetic information
in all living cells. The 24 known aaRS families are divided into 2 structurally distinct classes …

Accurate translation of mRNA into protein is vital for maintenance of cellular integrity.
Translational fidelity is achieved by two key events: synthesis of correctly paired aminoacyl …

The aminoacyl‐tRNA synthetases are an ancient group of enzymes that catalyze the
covalent attachment of an amino acid to its cognate transfer RNA. The question of specificity …

Editing reactions catalyzed by aminoacyl-tRNA synthetases are critical for accurate
translation of the genetic code. To date, this activity, whereby misactivated amino acids are …

Aminoacyl-tRNA synthetases (aaRS) are the enzymes that ensure faithful transmission of
genetic information in all living cells, and are central to the developing technologies for …

The site-specific incorporation of unnatural amino acids (UAAs) into proteins in living cells
relies on an engineered tRNA/aminoacyl-tRNA synthetase (tRNA/aaRS) pair, orthogonal to …