The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …

The thick ascending limb occupies a central anatomic and functional position in human
renal physiology, with critical roles in the defense of the extracellular fluid volume, the …

Renal ammonia metabolism and transport mediates a central role in acid-base homeostasis.
In contrast to most renal solutes, the majority of renal ammonia excretion derives from …

Acid-base homeostasis is critical to maintenance of normal health. Renal ammonia
excretion is the quantitatively predominant component of renal net acid excretion, both …

Renal ammonia excretion is the predominant component of renal net acid excretion. The
majority of ammonia excretion is produced in the kidney and then undergoes regulated …

The Na+/H+-exchanger 1, NHE1 (SLC9A1) and the electroneutral Na+, HCO3--
cotransporter NBCn1 (SLC4A7) are coexpressed in a wide range of tissues. Under normal …

The renal collecting system serves the fine-tuning of renal acid–base secretion. Acid-
secretory type-A intercalated cells secrete protons via a luminally expressed V-type H+ …

Mammalian genomes contain 10 SLC4 genes that, between them, encode three Cl–HCO3
exchangers, five Na+-coupled HCO3 transporters (NCBTs), one reported borate transporter …

In prokaryotic and eukaryotic organisms, biochemical and physiological processes are
sensitive to changes in H+ activity. For these processes to function optimally, a variety of …

Genome‐wide association studies recently linked the locus for Na+, HCO3−‐cotransporter
NBCn1 (SLC4A7) to breast cancer susceptibility, yet functional insights have been lacking …