Fluorescence microscopy is one of the most powerful tools for elucidating the cellular
functions of proteins and other molecules. In many cases, the function of a molecule can be …

Fluorescence image co-localization analysis is widely utilized to suggest biomolecular
interaction. However, there exists some confusion as to its correct implementation and …

The Pearson correlation coefficient (PCC) and the Mander's overlap coefficient (MOC) are
used to quantify the degree of colocalization between fluorophores. The MOC was …

All positive strand RNA viruses are known to replicate their genomes in close association
with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family …

The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors,
yet the link between it and the ubiquitously expressed mechanosensitive ion channel …

The active properties of dendrites can support local nonlinear operations, but previous
imaging and electrophysiological measurements have produced conflicting views regarding …

Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the
underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is …

One of the most routine uses of fluorescence microscopy is colocalization, ie, the
demonstration of a relationship between pairs of biological molecules. Frequently this is …

Mitophagy is involved in sepsis‐induced acute lung injury (ALI). Bcl‐2 family proteins play
an important role in mitochondrial homeostasis. However, whether targeting Bcl‐2 proteins …

Quantitative colocalization analysis is an advanced digital imaging tool to characterize the
spatial expression of molecules of interest in immunofluorescence images obtained using …