Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is
critical in the regulation of developmental organogenesis, homeostasis and injury-repair …

The COVID-19 pandemic has emerged as a global health emergency due to its association
with severe pneumonia and relative high mortality. However, the molecular characteristics …

The lung is composed of airways and lung parenchyma, and the extracellular matrix (ECM)
contains the main building blocks of both components. The ECM provides physical support …

Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial
and immune cell function that are driven, at least in part, by infection. Analysis of …

Elastic fibers are extracellular components of higher vertebrates and confer elasticity and
resilience to numerous tissues and organs such as large blood vessels, lungs, and skin …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One
main pathological feature of COPD is the loss of functional alveolar tissue without adequate …

The mammalian airways are sensitive to inhaled stimuli, and airway diseases are
characterized by hypersensitivity to volatile stimuli, such as perfumes, industrial solvents …

Extracellular matrix (ECM) composition has an important role in determining airway
structure. We postulated that ECM lung composition of chronic obstructive pulmonary …

Rationale: Matrix metalloprotease (MMP)-9 is an elastolytic endopeptidase produced by
activated macrophages that may be involved in the development of human pulmonary …