Sleep is essential for brain function in a surprisingly diverse set of ways. In the short term,
lack of sleep leads to impaired memory and attention; in the longer term, it produces …

Epidemiological evidence demonstrates a link between air pollution exposure and the onset
and progression of cognitive impairment and Alzheimer's disease (AD). However, current …

Cerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute
transport and the exchange of brain waste products. CSF flow is thus important for brain …

Glymphatic fluid transport eliminates metabolic waste from the brain including amyloid-β, yet
the methodology for studying efflux remains rudimentary. Here, we develop a method to …

Objectives Glymphatic function has not yet been explored in behavioral variant
frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic …

It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer's disease
(AD), first accumulates cortically in the default mode network (DMN), years before AD …

In the past, water homeostasis of the brain was understood as a certain quantitative
equilibrium of water content between intravascular, interstitial, and intracellular spaces …

Mammalian sleep has been implicated in maintaining a healthy extracellular environment in
the brain. During wakefulness, neuronal activity leads to the accumulation of toxic proteins …

The cerebral waste clearance system (ie, glymphatic or intramural periarterial drainage)
works through a network of perivascular spaces (PVS). Dysfunction of this system likely …

In-vivo microscopical studies indicate that brain cerebrospinal fluid (CSF) transport driven by
blood vessel pulsations is reduced in the early stages of Alzheimer's disease (AD). We …