Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Involvement of lipids in Alzheimer's disease pathology and potential therapies

H Chew, VA Solomon, AN Fonteh - Frontiers in physiology, 2020 - frontiersin.org
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

ApoE4: an emerging therapeutic target for Alzheimer's disease

M Safieh, AD Korczyn, DM Michaelson - BMC medicine, 2019 - Springer
Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview

G Martemucci, P Portincasa, A Di Ciaula… - Mechanisms of Ageing …, 2022 - Elsevier
Aging is characterized by a progressive loss of tissue and organ function due to genetic and
environmental factors, nutrition, and lifestyle. Oxidative stress is one the most important …

[HTML][HTML] Gas chromatography-mass spectrometry-based analytical strategies for fatty acid analysis in biological samples

HH Chiu, CH Kuo - Journal of food and drug analysis, 2020 - Elsevier
Fatty acids play critical roles in biological systems. Imbalances in fatty acids are related to a
variety of diseases, which makes the measurement of fatty acids in biological samples …

Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer's disease

V Rudajev, J Novotny - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that is one of the most
devastating and widespread diseases worldwide, mainly affecting the aging population. One …

Peroxisome quality control and dysregulated lipid metabolism in neurodegenerative diseases

DS Jo, NY Park, DH Cho - Experimental & molecular medicine, 2020 - nature.com
In recent decades, the role of the peroxisome in physiology and disease conditions has
become increasingly important. Together with the mitochondria and other cellular …

In pursuit of healthy aging: effects of nutrition on brain function

TM Melzer, LM Manosso, S Yau, J Gil-Mohapel… - International journal of …, 2021 - mdpi.com
Consuming a balanced, nutritious diet is important for maintaining health, especially as
individuals age. Several studies suggest that consuming a diet rich in antioxidants and anti …

[HTML][HTML] Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial

A Sala-Vila, C Valls-Pedret, S Rajaram… - The American journal of …, 2020 - Elsevier
Background Walnut consumption counteracts oxidative stress and inflammation, 2 drivers of
cognitive decline. Clinical data concerning effects on cognition are lacking. Objectives The …

Fats for thoughts: an update on brain fatty acid metabolism

A Romano, JB Koczwara, CA Gallelli, D Vergara… - The international journal …, 2017 - Elsevier
Brain fatty acid (FA) metabolism deserves a close attention not only for its energetic aspects
but also because FAs and their metabolites/derivatives are able to influence many neural …