Reactive oxygen species and cancer paradox: to promote or to suppress?
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …
increasingly being appreciated as powerful signaling molecules involved in the regulation of …
Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy
NS Aboelella, C Brandle, T Kim, ZC Ding, G Zhou - Cancers, 2021 - mdpi.com
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
AGE-RAGE synergy influences programmed cell death signaling to promote cancer
Advanced glycation end products (AGEs) are formed as a result of non-enzymatic reaction
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …
between the free reducing sugars and proteins, lipids, or nucleic acids. AGEs are …
Intracrine androgens and AKR1C3 activation confer resistance to enzalutamide in prostate cancer
The introduction of enzalutamide and abiraterone has led to improvement in the treatment of
metastatic castration-resistant prostate cancer. However, acquired resistance to …
metastatic castration-resistant prostate cancer. However, acquired resistance to …
Inhibition of AKR1C3 activation overcomes resistance to abiraterone in advanced prostate cancer
C Liu, CM Armstrong, W Lou, A Lombard… - Molecular cancer …, 2017 - AACR
Abiraterone suppresses intracrine androgen synthesis via inhibition of CYP17A1. However,
clinical evidence suggests that androgen synthesis is not fully inhibited by abiraterone and …
clinical evidence suggests that androgen synthesis is not fully inhibited by abiraterone and …
Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects
V Thiruchenthooran, E Sánchez-López, A Gliszczyńska - Cancers, 2023 - mdpi.com
Simple Summary The application of non-steroidal anti-inflammatory drugs (NSAIDs) in
cancer therapy has been a widely studied topic for almost four decades. This review …
cancer therapy has been a widely studied topic for almost four decades. This review …
PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity
Highlights•NSAIDs have anticancer activity but have toxicities resulting from COX
inhibition.•The mechanism of NSAID anticancer activity may not require COX …
inhibition.•The mechanism of NSAID anticancer activity may not require COX …
Improved melanoma suppression with target-delivered TRAIL and Paclitaxel by a multifunctional nanocarrier
S Huang, Y Zhang, L Wang, W Liu, L Xiao, Q Lin… - Journal of Controlled …, 2020 - Elsevier
Malignant melanoma, a highly dangerous type of skin cancer, is usually resistant to pro-
apoptosis agents such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) …
apoptosis agents such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) …
Nonsteroidal Anti-inflammatory Organometallic Anticancer Compounds
E Paunescu, S McArthur, M Soudani… - Inorganic …, 2016 - ACS Publications
Compounds that combine metal-based drugs with covalently linked targeted organic agents
have been shown, in some instances, to exhibit superior anticancer properties compared to …
have been shown, in some instances, to exhibit superior anticancer properties compared to …
Synthesis of folate targeted theranostic cubosomal platform for co-delivery of bismuth oxide and doxorubicin to melanoma in vitro and in vivo
Liquid crystalline nanoparticles (LCNPs) have gained much attention in cancer
nanomedicines due to their unique features such as high surface area, storage stability, and …
nanomedicines due to their unique features such as high surface area, storage stability, and …