While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

Background Temporal lobe epilepsy is a common and frequently intractable seizure
disorder. Its pathogenesis is thought to involve large-scale alterations to the expression of …

Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

The blood–brain barrier (BBB) is a dynamic and complex system which separates the brain
from the blood. It helps to maintain the homeostasis of the brain, which is essential for …

Neurodegenerative diseases are typically late-onset, progressive disorders that affect neural
function and integrity. Although most attention has been focused on the genetic …

MicroRNAs (miRNAs) have been proposed as biomarkers for cancer and other diseases
due to their stability in serum. In epilepsy, miRNAs have almost been studied in brain tissues …

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene
expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to …

Background There are no blood-based molecular biomarkers of temporal lobe epilepsy
(TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong …

Neuroinflammation is associated with the pathogenesis of many neurological disorders
including Parkinson's disease, Alzheimer's disease, Amyotrophic lateral sclerosis and …

Purpose ATP is an essential transmitter/cotransmitter in neuron function and
pathophysiology and has recently emerged as a potential contributor to prolonged seizures …