Recent advances in cryo-electron microscopy have marked only the beginning of the
potential of this technique. To bring structure into cell biology, the modality of cryo-electron …

Actin plays many well-known roles in cells, and understanding any specific role is often
confounded by the overlap of multiple actin-based structures in space and time. Here, we …

The phylum Apicomplexa comprises important eukaryotic parasites that invade host tissues
and cells using a unique mechanism of gliding motility. Gliding is powered by actomyosin …

Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …

Cristae membrane state plays a central role in regulating mitochondrial function and cellular
metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists …

A fundamental role of membrane-bound organelles is the compartmentalization and
organization of cellular processes. Mitochondria perform an immense number of metabolic …

Microglia nodules (HLA-DR+ cell clusters) are associated with brain pathology. In this post-
mortem study, we investigated whether they represent the first stage of multiple sclerosis …

Division of intracellular organelles often correlates with additional membrane wrapping, eg,
by the endoplasmic reticulum or the outer mitochondrial membrane. Such wrapping plays a …

The three-dimensional organization of biomolecules important for the functioning of all living
systems can be determined by cryo-electron tomography imaging under native biological …

Apoptosis is a form of regulated cell death essential for tissue homeostasis and embryonic
development. Apoptosis also plays a key role during bacterial infection, yet some …