Recently, in silico techniques have gained tremendous popularity in the field of small
molecule drug discovery. The computational jobs include not only hit generation, lead …

In recent decades, molecular hybridization has proven to be an efficient tool for obtaining
new synthetic molecules to treat different diseases. Based on the core idea of covalently …

A series of quinazolinone derivatives (7a–7h) were synthesized as antiproliferative agents.
All compounds, were synthesized through three steps method and structurally evaluated by …

Colorectal cancer (CRC) and breast cancer are leading causes of death globally, due to
significant challenges in detection and management. The late-stage diagnosis and …

A new series of 2-amino-1, 4-naphthoquinone-benzamides 5a-n was designed based on
previously reported potent cytotoxic agents. These compounds were synthesized from the …

Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

A series of 2-aryl/alkyl-2, 3-dihydro-1 H-naphtho [1, 2-e][1, 3] oxazines (S 1–S 11) were
synthesized with an eco-friendly and recoverable nanocatalyst (GO-Fe3O4–Ti (IV)) as an …

Background Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute
myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively …

We synthesized ten enamine naphthoquinones with yields ranging from 43 to 76%. These
compounds were screened for their in vitro antiproliferative activities by MTT assay against …

Abstract c-Met receptor tyrosine kinase has recently emerged as an important target with
therapeutic implications in pancreatic cancer. In this study, we carried out a docking virtual …