The endogenous opioid system consists of three opioid peptide precursor genes encoding
enkephalins (preproenkephalin, Penk), dynorphins (preprodynorphin, Pdyn) and β …

The recently discovered endogenous opioid peptides, endomorphins-1 and-2, appear to
have properties consistent with neurotransmitter/neuromodulator actions in mammals. This …

The catabolism of the endomorphins was investigated in detail. The endomorphins were
degraded relatively slowly in the rat brain homogenate (t1/2 (endomorphin-1)= 4.94 min; t1/2 …

Endomorphins (EMs) are endogenous selective μ-opioid receptor agonists. Their role in
inflammatory pain has not been fully elucidated. Here we examine peripheral …

Autism is a pervasive disorder characterized by a complex symptomatology, based
principally on social dysfunction. The disorder has a highly complex, largely genetic …

Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid
receptor (MOR), whereas naloxone, with only slight structural changes compared to …

Afferent endogenous opioid neuronal systems facilitate prolactin secretion in a number of
physiological conditions including pregnancy and lactation, by decreasing …

Recent statistics from the World Health Organization indicate that a high percentage of
people worldwide suffer from a wide variety of acute or cancer‐associated chronic pain. At …

Endomorphins-1 and-2 were substituted with all the β-MePhe stereoisomers in their Phe
residues to generate a conformationally constrained peptide set. This series of molecules …

Opioid peptides and their G-protein-coupled receptors (δ, κ μ) are located in the central
nervous system and peripheral tissues. The opioid system has been studied to determine …