Recently published work and emerging research efforts have suggested that the olfactory
system is intimately linked with the endocrine systems that regulate or modify energy …

Insulin is now well-established as playing multiple roles within the brain, and specifically as
regulating hippocampal cognitive processes and metabolism. Impairments to insulin …

Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune
diseases. Here we demonstrate that disease-associated autoreactive T cells from patients …

Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million
people worldwide, and is associated with central nervous system (CNS) disruption in at least …

Electrophysiological and pharmacological studies coupled with molecular identification
have revealed a unique network of ion channels—Kv1. 3, KCa3. 1, CRAC (Orai1+ Stim1) …

The insulin-regulated glucose transporter-4 (GluT4) is critical for insulin-and contractile-
mediated glucose uptake in skeletal muscle. GluT4 is also expressed in some hippocampal …

Background: The endogenous cannabinoid system participates in the regulation of energy
balance, and its dysregulation may be implicated in the pathogenesis of obesity. Adipose …

Introduction: The voltage-dependent potassium channel Kv1. 3 is mainly present in the
nervous and immune systems. In leukocytes, Kv1. 3 fine-tunes the activation and …

Voltage-gated potassium channels play a key role in human physiology and pathology.
Reflecting their importance, numerous channelopathies have been characterised that arise …

Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1. 3 channel …