Calcium-independent phospholipases A2 and their roles in biological processes and diseases
Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …
Synthetic and Natural Inhibitors of Phospholipases A2: Their Importance for Understanding and Treatment of Neurological Disorders
WY Ong, T Farooqui, G Kokotos… - ACS chemical …, 2015 - ACS Publications
Phospholipases A2 (PLA2) are a diverse group of enzymes that hydrolyze membrane
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …
Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages
Phospholipase A 2 s generate lipid mediators that constitute an important component of the
integrated response of macrophages to stimuli of the innate immune response. Because …
integrated response of macrophages to stimuli of the innate immune response. Because …
Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2
A Nikolaou, MG Kokotou, S Vasilakaki… - Biochimica et Biophysica …, 2019 - Elsevier
Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …
[HTML][HTML] Lipidomics of phospholipase A2 reveals exquisite specificity in macrophages
GM Murawska, AM Armando, EA Dennis - Journal of Lipid Research, 2024 - Elsevier
Abstract Phospholipase A 2 (PLA 2) constitutes a superfamily of enzymes that hydrolyze
phospholipids at their sn-2 fatty acyl position. Our laboratory has demonstrated that PLA 2 …
phospholipids at their sn-2 fatty acyl position. Our laboratory has demonstrated that PLA 2 …
The design and discovery of phospholipase A2 inhibitors for the treatment of inflammatory diseases
CS Batsika, ADD Gerogiannopoulou… - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Phospholipase A2 (PLA2) enzymes are implicated in several pathological
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …
Molecular basis of unique specificity and regulation of group VIA calcium-independent phospholipase A2 (PNPLA9) and its role in neurodegenerative diseases
D Hayashi, EA Dennis - Pharmacology & therapeutics, 2023 - Elsevier
Glycerophospholipids are major components of cell membranes and consist of a glycerol
backbone esterified with one of over 30 unique fatty acids at each of the sn-1 and sn-2 …
backbone esterified with one of over 30 unique fatty acids at each of the sn-1 and sn-2 …
Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016)
MG Kokotou, D Limnios, A Nikolaou… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: The regulation of the catalytic activity of the various phospholipase A2 enzymes
is of high importance because these enzymes are involved in various pathological …
is of high importance because these enzymes are involved in various pathological …
The Contribution of Cytosolic Group IVA and Calcium-Independent Group VIA Phospholipase A2s to Adrenic Acid Mobilization in Murine Macrophages
Adrenic acid (AA), the 2-carbon elongation product of arachidonic acid, is present at
significant levels in membrane phospholipids of mouse peritoneal macrophages. Despite its …
significant levels in membrane phospholipids of mouse peritoneal macrophages. Despite its …
[HTML][HTML] Unveiling the Role of iPLA2β in Neurodegeneration: From Molecular Mechanisms to Advanced Therapies
J Liu, J Tan, B Tang, J Guo - Pharmacological Research, 2024 - Elsevier
Calcium-independent phospholipase A 2 β (iPLA 2 β), a member of the phospholipase A2
(PLA2s) superfamily, is encoded by the PLA2G6 gene. Mutations in the PLA2G6 gene have …
(PLA2s) superfamily, is encoded by the PLA2G6 gene. Mutations in the PLA2G6 gene have …