There is a steady increase in the number of overweight and obese people worldwide and
increasingly, younger people. Excess adipose tissue impairs the action of insulin, leading to …

Gestational diabetes mellitus (GDM) and polycystic ovarian syndrome (PCOS) represent two
of the highest risk factors for development of type 2 diabetes mellitus in young women. As …

Aims/hypothesis Excess adiposity, insulin resistance and beta cell dysfunction each
contribute to the development of prediabetes (impaired glucose tolerance and/or impaired …

The distribution of adipose tissue is influenced by gender and by age, shifting from
subcutaneous to visceral depots with longevity, increasing the development of several aging …

Metabolic effects of glucagon-like peptide 1 (GLP-1) receptor agonists are confounded by
weight loss and not fully recapitulated by increasing endogenous GLP-1. We tested the …

Insulin resistance (IR) is a hallmark of type 2 diabetes, metabolic syndrome and
cardiometabolic risk. An epigenetic phenomena such as DNA methylation might be involved …

The circadian clock regulates the daily rhythms of several physiological and behavioral
processes. Disruptions in clock genes have been associated with obesity and related …

OBJECTIVE Alleviation of unrecognized glucotoxicity, with resultant recovery of β-cell
function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the …

Introduction Dopamine (DA) is a neurotransmitter that regulates the rewarding and
motivational processes underlying food intake and eating behaviors. This study …

Insulin sensitivity, pancreatic β-cell function, fasting glucose, and 2-h post-load glucose were
related to cognition in cognitively healthy nondiabetic older adults. Thirty-five adults (⩾ 65 …