Fundamentals and developments in fluorescence-guided cancer surgery

JSD Mieog, FB Achterberg, A Zlitni… - Nature reviews Clinical …, 2022 - nature.com
Fluorescence-guided surgery using tumour-targeted imaging agents has emerged over the
past decade as a promising and effective method of intraoperative cancer detection. An …

Near‐infrared‐II molecular dyes for cancer imaging and surgery

S Zhu, R Tian, AL Antaris, X Chen, H Dai - Advanced Materials, 2019 - Wiley Online Library
Fluorescence bioimaging affords a vital tool for both researchers and surgeons to
molecularly target a variety of biological tissues and processes. This review focuses on …

EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients: a phase II trial

JG de Wit, J Vonk, FJ Voskuil, SAHJ de Visscher… - Nature …, 2023 - nature.com
Inadequate surgical margins occur frequently in oral squamous cell carcinoma surgery.
Fluorescence molecular imaging (FMI) has been explored for intraoperative margin …

Latest developments in molecular tracers for fluorescence image-guided cancer surgery

S Hernot, L van Manen, P Debie, JSD Mieog… - The lancet …, 2019 - thelancet.com
Real-time intraoperative guidance is essential during oncological surgery for complete and
safe tumour resection. Fluorescence imaging in the near-infrared spectrum has shown …

Real-time fluorescence imaging in intraoperative decision making for cancer surgery

LJ Lauwerends, PBAA van Driel, RJB de Jong… - The Lancet …, 2021 - thelancet.com
Fluorescence-guided surgery is an intraoperative optical imaging method that provides
surgeons with real-time guidance for the delineation of tumours. Currently, in phase 1 and 2 …

Near-infrared fluorophores for biomedical imaging

G Hong, AL Antaris, H Dai - Nature biomedical engineering, 2017 - nature.com
In vivo near-infrared (NIR) fluorescence imaging is an emerging biomedical imaging
modality for use in both fundamental scientific research and clinical practice. Owing to …

Photobleaching of organic fluorophores: quantitative characterization, mechanisms, protection

AP Demchenko - Methods and applications in fluorescence, 2020 - iopscience.iop.org
Photochemical stability is one of the most important parameters that determine the
usefulness of organic dyes in different applications. This Review addresses key factors that …

Fluorescence image-guided tumour surgery

K Wang, Y Du, Z Zhang, K He, Z Cheng, L Yin… - Nature Reviews …, 2023 - nature.com
Intraoperative fluorescent imaging can provide real-time identification of tumours, lymph
nodes, nerves and other healthy and malignant tissues during oncological surgery …

Diverse applications of nanomedicine

B Pelaz, C Alexiou, RA Alvarez-Puebla, F Alves… - ACS …, 2017 - ACS Publications
The design and use of materials in the nanoscale size range for addressing medical and
health-related issues continues to receive increasing interest. Research in nanomedicine …

Fluorescence-guided surgery

T Nagaya, YA Nakamura, PL Choyke… - Frontiers in …, 2017 - frontiersin.org
Surgical resection of cancer remains an important treatment modality. Despite advances in
preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate …