The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

TH Karlsen, N Sheron, S Zelber-Sagi, P Carrieri… - The Lancet, 2022 - thelancet.com
Executive summary Liver diseases have become a major health threat across Europe, and
the face of European hepatology is changing due to the cure of viral hepatitis C and the …

Multimorbidity

ST Skou, FS Mair, M Fortin, B Guthrie… - Nature Reviews …, 2022 - nature.com
Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

[HTML][HTML] Framework for the development and evaluation of complex interventions: gap analysis, workshop and consultation-informed update

K Skivington, L Matthews, SA Simpson… - Health technology …, 2021 - ncbi.nlm.nih.gov
Background The Medical Research Council published the second edition of its framework in
2006 on developing and evaluating complex interventions. Since then, there have been …

Examining variation in the measurement of multimorbidity in research: a systematic review of 566 studies

ISS Ho, A Azcoaga-Lorenzo, A Akbari… - The Lancet Public …, 2021 - thelancet.com
Background A systematic understanding of how multimorbidity has been constructed and
measured is unavailable. This review aimed to examine the definition and measurement of …

An update on the clinical consequences of polypharmacy in older adults: a narrative review

JW Wastesson, L Morin, ECK Tan… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Polypharmacy, the use of multiple medications by one individual, is
increasingly common among older adults. Caring for the growing number of older people …

Physical multimorbidity, health service use, and catastrophic health expenditure by socioeconomic groups in China: an analysis of population-based panel data

Y Zhao, R Atun, B Oldenburg, B McPake… - The Lancet Global …, 2020 - thelancet.com
Background Multimorbidity, the presence of two or more mental or physical chronic non-
communicable diseases, is a major challenge for the health system in China, which faces …

Multimorbidity and functional impairment–bidirectional interplay, synergistic effects and common pathways

A Calderón‐Larrañaga, DL Vetrano… - Journal of internal …, 2019 - Wiley Online Library
This review discusses the interplay between multimorbidity (ie co‐occurrence of more than
one chronic health condition in an individual) and functional impairment (ie limitations in …

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort

M Nowakowska, SS Zghebi, DM Ashcroft, I Buchan… - BMC medicine, 2019 - Springer
Background The presence of additional chronic conditions has a significant impact on the
treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of …

Twelve-year clinical trajectories of multimorbidity in a population of older adults

DL Vetrano, A Roso-Llorach, S Fernández… - Nature …, 2020 - nature.com
Multimorbidity—the co-occurrence of multiple diseases—is associated to poor prognosis,
but the scarce knowledge of its development over time hampers the effectiveness of clinical …

Effect of social prescribing link workers on health outcomes and costs for adults in primary care and community settings: a systematic review

B Kiely, A Croke, M O'Shea, F Boland, E O'Shea… - BMJ open, 2022 - bmjopen.bmj.com
Objectives To establish the evidence base for the effects on health outcomes and costs of
social prescribing link workers (non-health or social care professionals who connect people …