Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …

The gastrointestinal tract contains trillions of microorganisms that exist symbiotically with the
host due to a tolerant, regulatory cell–rich intestinal immune system. However, this intimate …

Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among
the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain …

Brain vascular integrity is critical for brain health, and its disruption is implicated in many
brain pathologies, including psychiatric disorders. Brain-vascular barriers are a complex …

Traumatic brain injury is increasingly common in older individuals. Older age is one of the
strongest predictors for poor prognosis after brain trauma, a phenomenon driven by the …

Cranial bones constitute a protective shield for the vulnerable brain tissue, bound together
as a rigid entity by unique immovable joints known as sutures. Cranial sutures serve as …

Major depression is a significant medical issue impacting millions of individuals worldwide.
Identifying factors contributing to its manifestation has been a subject of intense investigation …

Highlights•Adaptive meningeal immune cells predominantly located around dural venous
sinuses.•Developing B cells, mature B cells and plasma cells present in dura in …

Immune surveillance of the brain plays an important role in health and disease. Peripheral
leukocytes patrol blood–brain barrier interfaces, and after injury, monocytes cross the …

The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are
protected by the blood-brain barrier that limits molecular, microbial and immunological …