The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
highly conserved, fundamental posttranslational modification (PTM). PARP catalytic …
Biology of poly (ADP-ribose) polymerases: the factotums of cell maintenance
P Bai - Molecular cell, 2015 - cell.com
The protein family of poly (ADP-ribose) polymerases (PARPs) or diphtheria toxin-type ADP-
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression
ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers
of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible …
of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible …
PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models
CW Wong, C Evangelou, KN Sefton, R Leshem… - Nature …, 2023 - nature.com
Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response
duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular …
duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular …
Genome-wide CRISPR screens in T helper cells reveal pervasive crosstalk between activation and differentiation
Summary T helper type 2 (Th2) cells are important regulators of mammalian adaptive
immunity and have relevance for infection, autoimmunity, and tumor immunology. Using a …
immunity and have relevance for infection, autoimmunity, and tumor immunology. Using a …
Genomics of adaptive evolution in the woolly mammoth
Ancient genomes provide a tool to investigate the genetic basis of adaptations in extinct
organisms. However, the identification of species-specific fixed genetic variants requires the …
organisms. However, the identification of species-specific fixed genetic variants requires the …
PARP14 regulates cyclin D1 expression to promote cell-cycle progression
MJ O'Connor, T Thakar, CM Nicolae, GL Moldovan - Oncogene, 2021 - nature.com
Cyclin D1 is an essential regulator of the G1–S cell-cycle transition and is overexpressed in
many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by …
many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by …
New directions in poly (ADP‐ribose) polymerase biology
FJ Bock, P Chang - The FEBS journal, 2016 - Wiley Online Library
Poly (ADP‐ribose) polymerases (PARP s) regulate the function of target proteins by
modifying them with ADP‐ribose, a large and unique post‐translational modification …
modifying them with ADP‐ribose, a large and unique post‐translational modification …
PARP14: a key ADP-ribosylating protein in host–virus interactions?
S Parthasarathy, AR Fehr - PLoS pathogens, 2022 - journals.plos.org
Over 300 posttranslational modifications (PTMs) are known to modify the functions of
proteins by affecting processes ranging from activation, degradation, localization, secretion …
proteins by affecting processes ranging from activation, degradation, localization, secretion …
Modulation of IL-4/IL-13 cytokine signaling in the context of allergic disease
A Shankar, JW McAlees, IP Lewkowich - Journal of Allergy and Clinical …, 2022 - Elsevier
Aberrant activation of CD4 TH 2 cells and excessive production of TH 2 cytokines such as IL-
4 and IL-13 have been implicated in the pathogenesis of allergic diseases. Generally, IL-4 …
4 and IL-13 have been implicated in the pathogenesis of allergic diseases. Generally, IL-4 …