Once and only once: mechanisms of centriole duplication and their deregulation in disease

EA Nigg, AJ Holland - Nature reviews Molecular cell biology, 2018 - nature.com
Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Mechanism and regulation of centriole and cilium biogenesis

DK Breslow, AJ Holland - Annual review of biochemistry, 2019 - annualreviews.org
The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Structure of the decorated ciliary doublet microtubule

M Ma, M Stoyanova, G Rademacher, SK Dutcher… - Cell, 2019 - cell.com
The axoneme of motile cilia is the largest macromolecular machine of eukaryotic cells. In
humans, impaired axoneme function causes a range of ciliopathies. Axoneme assembly …

CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity

MD Arslanhan, S Cengiz-Emek, E Odabasi… - Journal of Cell …, 2023 - rupress.org
Centrioles are microtubule-based organelles responsible for forming centrosomes and cilia,
which serve as microtubule-organizing, signaling, and motility centers. Biogenesis and …

[HTML][HTML] Centrioles, centrosomes, and cilia in health and disease

EA Nigg, JW Raff - Cell, 2009 - cell.com
Centrioles are barrel-shaped structures that are essential for the formation of centrosomes,
cilia, and flagella. Here we review recent advances in our understanding of the function and …

[HTML][HTML] Evolution: Tracing the origins of centrioles, cilia, and flagella

Z Carvalho-Santos, J Azimzadeh… - The Journal of cell …, 2011 - ncbi.nlm.nih.gov
Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …

[HTML][HTML] The vertebrate primary cilium in development, homeostasis, and disease

JM Gerdes, EE Davis, N Katsanis - Cell, 2009 - cell.com
Cilia are complex structures that have garnered interest because of their roles in vertebrate
development and their involvement in human genetic disorders. In contrast to multicellular …

A helical inner scaffold provides a structural basis for centriole cohesion

M Le Guennec, N Klena, D Gambarotto, MH Laporte… - Science …, 2020 - science.org
The ninefold radial arrangement of microtubule triplets (MTTs) is the hallmark of the
centriole, a conserved organelle crucial for the formation of centrosomes and cilia. Although …

Towards a molecular architecture of centriole assembly

P Gönczy - Nature reviews Molecular cell biology, 2012 - nature.com
The centriole is an evolutionarily conserved macromolecular structure that is crucial for the
formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first …

Regulating the transition from centriole to basal body

T Kobayashi, BD Dynlacht - Journal of Cell Biology, 2011 - rupress.org
The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of
spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase …