Background/Objectives: Rare diseases are a wide and heterogeneous group of multisystem
life-threatening or chronically debilitating clinical conditions with reduced life expectancy …

Drosophila melanogaster is unique among animal models because it has a fully defined
synthetic diet available to study nutrient-gene interactions. However, use of this diet is …

Inherited metabolic disorders are a group of genetic conditions that can cause severe
neurological impairment and child mortality. Uniquely, these disorders respond to dietary …

Short‐chain enoyl‐CoA hydratase 1 deficiency (ECHS1D) is a rare genetic disorder caused
by biallelic pathogenic variants in the ECHS1 gene. ECHS1D is characterised by severe …

Studies on antiaging remedies in insect models sometimes show discrepancies in results.
These discrepancies could be explained by different responses of short‐and long‐lived …

Organismal macronutrient intake modulates organ and tissue function. Dietary amino acids
play essential roles in metabolic processes that support normal tissue growth, repair, and …

Дисертація присвячена вивченню здатності альфа-кетоглютарату (АКГ), важливого
клітинного метаболіту, впливати на старіння та метаболічні порушення, які, зазвичай …