Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

JH Jiang, DR Cameron, C Nethercott… - Clinical microbiology …, 2023 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often
fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful …

Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections

PT Buckley, R Chan, J Fernandez, J Luo, KA Lacey… - Cell Host & Microbe, 2023 - cell.com
Treating and preventing infections by antimicrobial-resistant bacterial pathogens is a
worldwide problem. Pathogens such as Staphylococcus aureus produce an array of …

Targeting bacterial phospholipids and their synthesis pathways for antibiotic discovery

M Song, S Chen, W Lin, K Zhu - Progress in Lipid Research, 2024 - Elsevier
Bacterial infections in humans and animals caused by multidrug-resistant (MDR) pathogens
pose a serious threat to public health. New antibacterial targets are extremely urgent to …

Bacterial single-cell RNA sequencing captures biofilm transcriptional heterogeneity and differential responses to immune pressure

LE Korshoj, T Kielian - Nature Communications, 2024 - nature.com
Biofilm formation is an important mechanism of survival and persistence for many bacterial
pathogens. These multicellular communities contain subpopulations of cells that display …

Skin microbiome variation with cancer progression in human cutaneous squamous cell carcinoma

AY Voigt, A Emiola, JS Johnson, ES Fleming… - Journal of Investigative …, 2022 - Elsevier
The skin microbiome plays a critical role in skin homeostasis and disorders. UVR is the
major cause of nonmelanoma skin cancer, but other risk factors, including immune …

The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interaction

K Schilcher, MM Severn, C Jenul, YSC Avina… - PLoS …, 2024 - journals.plos.org
Lipoproteins of the opportunistic pathogen Staphylococcus aureus play a crucial role in
various cellular processes and host interactions. Consisting of a protein and a lipid moiety …

A magnetically controlled soft miniature robotic fish with a flexible skeleton inspired by zebrafish

C Huang, Z Lai, L Zhang, X Wu… - Bioinspiration & …, 2021 - iopscience.iop.org
The untethered miniature swimming robot actuation and control is difficult as the robot size
becomes smaller, due to limitations of feasible miniaturized on-board components. Nature …

Staphylococcus aureus prophage-encoded protein causes abortive infection and provides population immunity against Kayviruses

L Kuntová, I Mašlaňová, R Obořilová, H Šimečková… - Mbio, 2023 - Am Soc Microbiol
Both temperate and obligately lytic phages have crucial roles in the biology of staphylococci.
While superinfection exclusion among closely related temperate phages is a well …

Wall teichoic acids facilitate the release of toxins from the surface of Staphylococcus aureus

T Brignoli, E Douglas, S Duggan… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT A major feature of the pathogenicity of Staphylococcus aureus is its ability to
secrete cytolytic toxins. This process involves the translocation of the toxins from the …

The major autolysin atl regulates the virulence of staphylococcus aureus by controlling the sorting of lukAB

X Zheng, SX Ma, A St. John, VJ Torres - Infection and Immunity, 2022 - Am Soc Microbiol
Infections caused by the Gram-positive bacterium Staphylococcus aureus remain a
significant health threat globally. The production of bicomponent pore-forming leukocidins …