Nerve growth factor (NGF) is a neurotrophin that activates nociceptive neurons to transmit
pain signals from the peripheral to the central nervous system and that exerts its effects on …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …

Brain-derived neurotrophic factor (BDNF) is a small dimeric protein, structurally related to
nerve growth factor, which is abundantly and widely expressed in the adult mammalian …

The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-
derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) …

Over a half a century of research has confirmed that neurotrophic factors promote the
survival and process outgrowth of isolated neurons in vitro. The mechanisms by which …

Neurotrophic factors comprise a broad family of biomolecules–most of which are peptides or
small proteins–that support the growth, survival and differentiation of both developing and …

The normal intervertebral disc (IVD) is a poorly innervated organ supplied only by sensory
(mainly nociceptive) and postganglionic sympathetic (vasomotor efferents) nerve fibers …

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …