Highlights•Mitochondria are involved in various physiochemical and biochemical
processes.•Owing to their crucial role in cellular metabolism, mitochondria are favored …

Many diseases originate from alterations at nanoscale levels. Precise drug delivery should
be achieved not only at cell level, but also at organelle level to achieve maximum …

For specific targeting of cancer tissues, adequate information about the cancer tissue
environment, cancer cell pathology, and available methods and limits of such methods is …

Cathepsins are an important category of enzymes that have attracted great attention for the
delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug …

Cancer is characterized by abnormal cell differentiation in or on the part of the body. The
most commonly used chemotherapeutic drugs are developed to target rapidly dividing cells …

Introduction: Recent trends in drug delivery indicate a steady increase in the use of targeted
therapeutics to enhance the specific delivery of biologically active payloads to diseased …

To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting
to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing …

Curcumin can induce cancer cell apoptosis through lysosomal permeabilization pathway.
However, the poor selectivity of curcumin restricts its use in the therapy of hepatocellular …

With environmental and resource issues become increasingly prominent, as well as the
requirements of the bioeconomy, the synthesis of polyurethane tends to follow the green …

Background Since cancer cells are normally over-expressed cathepsin B, we synthesized
dendrimer-methoxy poly (ethylene glycol)(MPEG)-doxorubicin (DOX) conjugates using a …