Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …

Bioisosterism is one of the leading strategies in medicinal chemistry for the design and
modification of drugs, consisting in replacing an atom or a substituent with a different atom or …

Background: Human HDACs represent a group of enzymes able to modify histone and non-
histone proteins, which interact with DNA to generate chromatin. The correlation between …

Histone deacetylases (HDACs) are critical epigenetic drug targets that have gained
significant attention in the scientific community for the treatment of cancer. The currently …

Gastric cancer (GC) poses a serious threat worldwide with unfavorable prognosis mainly
due to late diagnosis and limited therapies. Therefore, precise molecular classification and …

Late‐stage colorectal cancer (CRC) is still a clinically challenging problem. The activity of
the tumor suppressor p53 is regulated via post‐translational modifications (PTMs). While the …

In anticancer drug discovery, multi-targeting compounds have been beneficial due to their
advantages over single-targeting compounds. For instance, VEGFR-2 has a crucial role in …

Keloids are benign fibrous overgrowths that occur as a result of abnormal wound healing
following cutaneous injury. MicroRNAs (miRNAs/miRs) are short non‑coding RNAs that …

Exosomes play crucial roles in intercellular communication, including tumor metastasis.
Panobinostat (LBH589), a histone deacetylases (HDAC) inhibitor, is an emerging anti-tumor …

Pyrrole is a biologically active scaffold, which itself possess noticeable anticancer activity
against several types of cancer specially leukemia, lymphoma, and myelofibrosis. SAHA and …