Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

The iTRAQ (isobaric tags for relative and absolute quantification) technique is widely
employed in proteomic workflows requiring relative quantification. Here, we review the …

Over the past decade, chemical labeling with isobaric tandem mass tags, such as isobaric
tags for relative and absolute quantification reagents (iTRAQ) and tandem mass tag (TMT) …

Protein glycosylation plays key roles in many biological processes. In addition, alterations in
protein glycosylation have been related to different diseases, as well as may affect the …

Human saliva harbours proteins of clinical relevance and about 30% of blood proteins are
also present in saliva. This highlights that saliva can be used for clinical applications just as …

Pancreatic cancer is a lethal disease where specific early detection biomarkers would be
very valuable to improve outcomes in patients. Many previous studies have compared …

Studies aimed toward glycan biomarker discovery have focused on glycan characterization
by the global profiling of released glycans. Site-specific glycosylation analysis is less …

In this paper, we present two complementary strategies for enrichment of glycoproteins on
living cells that combine the desirable attributes of “robust enrichment” afforded by covalent …

Glycoproteins fulfill many indispensable biological functions, and changes in protein
glycosylation have been observed in various diseases. Improved analytical methods are …