Optimizing haemophilia care in resource-limited countries: Current challenges and future prospects

A Ndoumba-Mintya, YL Diallo, TC Tayou… - Journal of Blood …, 2023 - Taylor & Francis
About 75% of persons with hemophilia live in the developing world and do not have access
to routine care due to many barriers. There are a lot of challenges associated with …

Stepwise options for preparing therapeutic plasma proteins from domestic plasma in low‐and middle‐income countries

T Burnouf, J Epstein, JC Faber, WM Smid… - Vox …, 2024 - Wiley Online Library
Industrial plasma fractionation, a complex and highly regulated technology, remains largely
inaccessible to many low‐and middle‐income countries (LMICs). This, combined with the …

Future needs for continuing innovation in hemophilia: improving outcomes for individuals of all severities, including women and those in resource-constrained regions

J Blatný, J Astermark, C Catarino… - Therapeutic …, 2024 - journals.sagepub.com
Over recent decades, management of people with hemophilia (PwH) has been greatly
improved by scientific advances that have resulted in a rich and varied therapeutic …

Clinical burden of hemophilia in older adults: beyond bleeding risk

MH Hodroj, G El Hasbani, HO Al-Shamsi, H Samaha… - Blood Reviews, 2022 - Elsevier
The prospect of hemophilia patients has dramatically improved in the last few decades with
the introduction of various interventions that can effectively treat or prevent their bleeding …

Building Capacity for Pediatric Hematological Diseases in Sub-Saharan Africa

LF Chirande, R Namazzi, M Hockenberry… - Blood …, 2024 - ashpublications.org
The spectrum of hematological diseases in African children includes anemias, bleeding
disorders, thromboses, and oncological diseases such as leukemias. While data are limited …

[HTML][HTML] The road to implementation of pharmacokinetic-guided dosing of factor replacement therapy in hemophilia and allied bleeding disorders. Identifying …

TMHJ Goedhart, A Janssen, RAA Mathôt, MH Cnossen… - Blood Reviews, 2023 - Elsevier
Clinical guidelines and expert groups recommend the use of pharmacokinetic (PK)-guided
dosing of factor replacement therapy for the treatment of bleeding disorders, especially for …

[HTML][HTML] Economic evaluation of immune tolerance induction in children with severe hemophilia A and high-responding inhibitors: a cost-effectiveness analysis of …

RM Camelo, MM Barbosa, MS Araújo… - Value in Health …, 2023 - Elsevier
Objective This study aimed to measure the cost-effectiveness of prophylaxis with
emicizumab in PsHAhri on ITI in Brazil. Methods A cost-effectiveness modeling analysis was …

[HTML][HTML] Emicizumab prophylaxis for people with hemophilia A: Waste estimation and the Brazilian perspective

RM Camelo, MM Barbosa, LCM Henriques… - Saudi Pharmaceutical …, 2023 - Elsevier
Costs of hemophilia A treatment are increasing. Waste of clotting products should be
avoided. To estimate the first-year waste of emicizumab prophylaxis for people with …

Haemophilia B in Algeria: Realities and therapeutic perspectives

MS Nekkal, N Mesli, F Grifi, N Cherif… - …, 2023 - Wiley Online Library
Introduction Haemophilia B is a debilitating hereditary coagulation disorder characterized by
prolonged or spontaneous episodes of bleeding caused by a deficiency of endogenous …

[HTML][HTML] Expert Opinions on the Management of Hemophilia A in India: The Role of Emicizumab

N Gupta, A Dutta, B Ahmed, CR Ross, S Chandrakala… - Cureus, 2024 - ncbi.nlm.nih.gov
Hemophilia A (HA) is a genetic disorder of hemostasis associated with a deficiency or
reduced activity of clotting factor VIII (FVIII). This disorder remains unacceptably …