WNT/β-catenin signaling is involved in many physiological processes. Its implication in
embryonic development, cell migration, and polarization has been shown. Nevertheless …

Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The Wnt/β-catenin
pathway plays critical roles in regulating embryonic development and physiological …

Ovarian cancer is one of the most lethal gynecologic cancers. The standard therapy for
ovarian cancer has been the same for the past two decades, a combination treatment of …

Background Little is known about mechanisms of resistance to poly (adenosine diphosphate-
ribose) polymerase inhibitors (PARPi) and platinum chemotherapy in patients with …

Despite the high initial response rates to PARP inhibitors (PARPi) in BRCA-mutated
epithelial ovarian cancers (EOC), PARPi resistance remains a major challenge. Chemical …

Epithelial-derived high-grade serous ovarian cancer (HGSOC) is the deadliest gynecologic
malignancy. Roughly 80% of patients are diagnosed with late-stage disease, which is …

Since the discovery of the first mammalian Wnt proto-oncogene in virus-induced mouse
mammary tumors almost four decades ago, Wnt signaling pathway and its involvement in …

The use of PARP inhibitors (PARPi) is growing widely as FDA approvals have shifted its use
from the recurrence setting to the frontline setting. In parallel, the population developing …

Background Euchromatic histone-lysine-N-methyltransferases 1 and 2 (EHMT1/2, aka
GLP/G9A) catalyze dimethylation of histone H3 lysine 9 (H3K9me2) and have roles in …

Gynecologic malignancies, including ovarian cancer, endometrial cancer, and cervical
cancer, affect hundreds of thousands of women worldwide every year. Wnt signaling …