This article reviews the major physiological and physicochemical principles of the effect of
food and gastrointestinal (GI) pH on the absorption and bioavailability of oral drugs, and the …

The bioavailability of an orally administered small molecule is often dictated by drug-specific
physicochemical characteristics and is influenced by many biological processes. For …

Microbiome-encoded β-glucuronidase (GUS) enzymes play important roles in human health
by metabolizing drugs in the gastrointestinal (GI) tract. The numbers, types, and diversity of …

Growth impairment is a major public health issue for children in Tanzania. The question
remains as to whether dietary mycotoxins play a role in compromising children's growth. We …

Background Dihydromyricetin (DMY) is an important plant flavonoid, which has received
great attention due to its health-benefiting activities, including antioxidant, antimicrobial, anti …

Enteric coating is a common procedure in the development of oral pharmaceutical dosage
forms. The main advantage of enteric coating is that it protects the drug from acidic pH and …

Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …

In case of colon-specific delivery of therapeutic agents through oral route, microbial/enzyme-
triggered release approach has several advantages over other approaches due to unique …

Gut microbiota has been reported to be closely related to host energy metabolism and
immunity, and thus influence the development and progression of various human diseases …

Obesity is a pathophysiological state defined by a body mass index> 30 kg/m 2 and
characterized by an adipose tissue accumulation leading to an important weight increased …