l-Asparaginase has gained much attention for effectively treating acute lymphoblastic
leukemia (ALL) and mitigating carcinogenic acrylamide in fried foods. Due to high-dose …

Genetic engineering for heterologous expression has advanced in recent years. Model
systems such as Escherichia coli, Bacillus subtilis and Pichia pastoris are often used as host …

Heterologous expression of L-asparaginase (L-ASNase) has become an important area of
research due to its clinical and food industry applications. This review provides a …

Abstract L-asparaginase (L-ASNase) is an enzyme that catalyzes the hydrolysis of L-
asparagine to L-aspartic acid and ammonia and is used to treat acute lymphoblastic …

Background Hepatocellular carcinoma (HCC) is among the common cancers, but difficult to
diagnose and treat. l-asparaginase has been introduced in the treatment protocol of …

Amino acid deprivation therapy (AADT) is a promising strategy for developing novel
anticancer treatments, based on variations in metabolism of healthy and malignant cells. L …

L-asparaginase is a remarkable antineoplastic enzyme used in medicine for the treatment of
acute lymphoblastic leukemia (ALL) as well as in food industries. In this work, the L …

L-asparaginases, which are oncolytic enzymes, have been used in clinical applications for
many years. These enzymes are also important in food processing industry due to their …

This work aimed to study the structural features and mechanisms of thermoinactivation of
hyperthermophilic L-asparaginase (L-ASNase) from archaea Thermococcus sibiricus (TsA) …

L-asparaginases (L-ASNases) of microbial origin are the mainstay of blood cancer
treatment. Numerous attempts have been performed for genetic improvement of the main …