Abstract Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …

Animal models have historically played a critical role in the exploration and characterization
of disease pathophysiology and target identification and in the evaluation of novel …

Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …

Diabetic patients are at increased risk of developing coronary artery disease and experience
worse clinical outcomes following acute myocardial infarction. Novel therapeutic strategies …

Preconditioning, postconditioning, and remote conditioning of the myocardium enhance the
ability of the heart to withstand a prolonged ischemia/reperfusion insult and the potential to …

Metabolic syndrome, diabetes, and ischemic heart disease are among the leading causes of
death and disability in Western countries. Diabetic cardiomyopathy is responsible for the …

The ability of adult cardiomyocytes to regenerate is limited, and irreversible loss by cell
death plays a crucial role in heart diseases. Autophagy is an evolutionarily conserved …

The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …

Mitochondrially bound hexokinase II (mtHKII) has long been known to confer cancer cells
with their resilience against cell death. More recently, mtHKII has emerged as a powerful …

As mediators of the first enzymatic step in glucose metabolism, hexokinases (HKs)
orchestrate a variety of catabolic and anabolic uses of glucose, regulate antioxidant power …