RhoA GTPase plays a variety of functions in regulation of cytoskeletal proteins, cellular
morphology, and migration along with various proliferation and transcriptional activity in …

Mutations in the GNAO1 gene cause a complex constellation of neurological disorders
including epilepsy, developmental delay, and movement disorders. GNAO1 encodes Gα o …

The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton
support neuronal morphogenesis. Small RhoGTPases family members have emerged as …

The transmembrane proteoglycan NG2 is expressed by oligodendrocyte precursor cells
(OPC), which migrate to axons during developmental myelination and remyelinate in the …

Despite decades of study, elucidation of the underlying etiology of complex developmental
disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ), intellectual …

Transfer RNA (tRNA) plays a role in stress response programs involved in various
pathological conditions including neurological diseases. Under cell stress conditions …

Zinc is an essential element required for cell division, migration, and proliferation. Under
zinc‐deficient conditions, proliferation and differentiation of neural progenitors are …

Small GTPases are known to regulate hundreds of cell functions. In particular, Rho family
GTPases are master regulators of the cytoskeleton. By regulating actin nucleation …

The proteasome inhibiter bortezomib has been successfully used to treat patients with
relapsed multiple myeloma; however, many of these patients become thrombocytopenic …

Two key proteins for cellular communication between astrocytes and neurons are αvβ3
integrin and the receptor Thy-1. Binding of these molecules in the same (cis) or on adjacent …