I. INTRODUCTION glossal motoneurons for genioglossus muscle that governs tongue
protrusion in inspiration (2'76, 333, 495); 2) naso-In mammals, the uptake of oxygen and …

Nausea and vomiting are among the most frequently occurring symptoms observed by
clinicians. While advances have been made in understanding both the physiological as well …

Advances in antiemetic therapy for chemotherapy-induced emesis have resulted in
improved protection against symptoms occurring within 24 h of chemotherapy. However, the …

Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes
and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the …

The cellular distribution of the type 3 serotonin receptor (5HT3R) in the rat brain was
established immunocytochemically by using a polyclonal antibody raised against a synthetic …

Placode-derived general visceral afferent neurons of the nodose ganglion transmit visceral
sensory information from specialized sensory endings of the vagus nerve and its branches …

The type 3 serotonin (5-HT3) receptor is the only ligand-gated ion channel receptor for
serotonin in vertebrates. Two 5-HT3 receptor subunits have been cloned, subunit A (5 …

Substitution of the chlorine atom by a radio‐iodine in position 5 in the zacopride molecule
yielded [125I] iodo‐zacopride that bound with high affinity (Kd= 4.3 nM) to 5‐HT3 receptors …

The main function of emesis is to remove toxins from the body. The emetic response will also
be triggered by cancer chemotherapy and radiotherapy or surgery under general …

In humans, there are large individual differences in the levels of vagal modulation of resting
heart rate (HR). High levels are a recognized index of cardiac health, whereas low levels are …