Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

LE Wroblewski, RM Peek Jr… - Clinical microbiology …, 2010 - Am Soc Microbiol
Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's
population. Infection with H. pylori causes chronic inflammation and significantly increases …

Helicobacter pylori and gastrointestinal tract adenocarcinomas

RM Peek Jr, MJ Blaser - Nature Reviews Cancer, 2002 - nature.com
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in
the stomach, only a small fraction of colonized individuals develop this common malignancy …

Activation of β-catenin by carcinogenic Helicobacter pylori

AT Franco, DA Israel, MK Washington… - Proceedings of the …, 2005 - National Acad Sciences
Persistent gastritis induced by Helicobacter pylori is the strongest known risk factor for
adenocarcinoma of the distal stomach, yet only a fraction of colonized persons ever develop …

Role of monocytes in atherogenesis

B Østerud, E Bjørklid - Physiological reviews, 2003 - journals.physiology.org
Østerud, Bjarne, and Eirik Bjørklid. Role of Monocytes in Atherogenesis. Physiol Rev 83:
1069-1112, 2003; 10.1152/physrev. 00005.2003.—This review focuses on the role of …

Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions

U Schönbeck, GK Sukhova, P Graber, S Coulter… - The American journal of …, 1999 - Elsevier
Cyclooxygenase-1 (Cox-1) and Cox-2 convert arachidonic acid to prostaglandin H2, the
precursor of other prostaglandins and thromboxanes, eicosanoids important in vascular …

Cyclooxygenase-2 biology

J Clària - Current pharmaceutical design, 2003 - ingentaconnect.com
In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of
phospholipase A2 and the release of arachidonic acid from membrane phospholipids in …

Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives

F Halter, AS Tarnawski, A Schmassmann, BM Peskar - Gut, 2001 - gut.bmj.com
Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two
isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract …

How bacteria could cause cancer: one step at a time

AJ Lax, W Thomas - Trends in microbiology, 2002 - cell.com
Helicobacter pylori highlighted the potential for bacteria to cause cancer. It is becoming clear
that chronic infection with other bacteria, notably Salmonella typhi, can also facilitate tumour …

Increased expression of cyclooxygenase-2 protein in human gastric carcinoma

HY Lim, HJ Joo, JH Choi, JW Yi, MS Yang, DY Cho… - Clinical cancer …, 2000 - AACR
Gastric adenocarcinoma is one of the most common malignancies in the world, and yet little
is known about its molecular process of development and progression. Recent studies have …

Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S.bovis )

J Biarc, IS Nguyen, A Pini, F Gosse, S Richert… - …, 2004 - academic.oup.com
Several studies reported linkage between bacterial infections and carcinogenesis.
Streptococcus bovis was traditionally considered as a lower grade pathogen frequently …