RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

[HTML][HTML] Innate immune evasion by human respiratory RNA viruses

M Kikkert - Journal of innate immunity, 2020 - karger.com
The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and …

Regulation of Viral Infection by the RNA Modification N6-Methyladenosine

GD Williams, NS Gokhale… - Annual review of virology, 2019 - annualreviews.org
In recent years, the RNA modification N6-methyladenosine (m6A) has been found to play a
role in the life cycles of numerous viruses and also in the cellular response to viral infection …

A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

S Yu, VN Kim - Nature Reviews Molecular Cell Biology, 2020 - nature.com
RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

Plant YTHDF proteins are direct effectors of antiviral immunity against an N6‐methyladenosine‐containing RNA virus

M Martínez‐Pérez, F Aparicio… - The EMBO …, 2023 - embopress.org
In virus–host interactions, nucleic acid‐directed first lines of defense that allow viral
clearance without compromising growth are of paramount importance. Plants use the RNA …

ER-associated RNA silencing promotes ER quality control

S Efstathiou, F Ottens, LS Schütter, S Ravanelli… - Nature Cell …, 2022 - nature.com
The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted
and endomembrane proteins. ER-associated degradation (ERAD) prevents the …

A mechanism for microRNA arm switching regulated by uridylation

H Kim, J Kim, S Yu, YY Lee, J Park, RJ Choi, SJ Yoon… - Molecular cell, 2020 - cell.com
Strand selection is a critical step in microRNA (miRNA) biogenesis. Although the dominant
strand may change depending on cellular contexts, the molecular mechanism and …

Naturally-associated bacteria modulate Orsay virus infection of Caenorhabditis elegans

R González, MA Félix - PLoS Pathogens, 2024 - journals.plos.org
Microbes associated with an organism can significantly modulate its susceptibility to viral
infections, but our understanding of the influence of individual microbes remains limited. The …

Innate immunity in C. elegans

CN Martineau, NV Kirienko, N Pujol - Current topics in developmental …, 2021 - Elsevier
In its natural habitat, C. elegans encounters a wide variety of microbes, including food,
commensals and pathogens. To be able to survive long enough to reproduce, C. elegans …

TENT5 cytoplasmic noncanonical poly (A) polymerases regulate the innate immune response in animals

V Liudkovska, PS Krawczyk, A Brouze, N Gumińska… - Science …, 2022 - science.org
Innate immunity is the first line of host defense against pathogens. Here, through global
transcriptome and proteome analyses, we uncover that newly described cytoplasmic poly …