Chronic diarrhea in diabetes mellitus: mechanisms and an approach to diagnosis and treatment

MA Valdovinos, M CAMILLERI… - Mayo Clinic …, 1993 - Elsevier
In this study, our aim was to develop a practical strategy to facilitate the management of
patients with diabetes mellitus and chronic diarrhea in a tertiary referral practice. We …

Histologic changes in diabetic gastroparesis

G Farrugia - Gastroenterology Clinics, 2015 - gastro.theclinics.com
The cellular abnormalities that lead to diabetic gastroparesis are increasingly being
understood. Several key cell types are affected by diabetes, leading to gastroparesis. These …

Loss of interstitial cells of cajal and inhibitory innervation in insulin-dependent diabetes

CL He, JH Szurszewski, G Farrugia, EE Soffer… - Gastroenterology, 2001 - Elsevier
Background & Aims: Gastrointestinal complications of long-standing diabetes include
nausea, vomiting, abdominal pain, diarrhea, and constipation. The pathophysiology …

Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease

P Milner, R Crowe, MA Kamm, JE Lennard-Jones… - Gastroenterology, 1990 - Elsevier
The distribution in the bowel wall of vasoactive intestinal polypeptide-, neuropeptide Y-, and
substance P-containing nerve cell bodies and nerve fibers has been described in human …

Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum

PRR Gangula, WL Maner, MA Micci… - American Journal …, 2007 - journals.physiology.org
Diabetic gastroparesis is a disorder that predominantly affects women. However, the
biological basis of this sex bias remains completely unknown. In this study we tested the …

Immunohistochemical measurements of nerves and neuropeptides in diabetic skin: relationship to tests of neurological function

DM Levy, G Terenghi, XH Gu, RR Abraham… - Diabetologia, 1992 - Springer
Image-analysis was used to measure nerves immunoreactive to the general neuronal
marker protein gene product 9.5 (PGP 9.5-IR) and the neuropeptides calcitonin gene-related …

Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats

HF Wrzos, A Cruz, R Polavarapu, D Shearer… - Digestive diseases and …, 1997 - Springer
Nitric oxide (NO) is an important inhibitoryneurotransmitter in the gut. Alterations in NO
mediatedresponses have been described in diabetic animals. Thepresence of nitric oxide …

There are no morphologic abnormalities of the gastric wall or abdominal vagus in patients with diabetic gastroparesis

MM Yoshida, MD Schuffler, SM Sumi - Gastroenterology, 1988 - Elsevier
Because there is evidence for vagal autonomic neuropathy as the cause of diabetic
gastroparesis, we hypothesized that this disorder should be associated with morphologic …

Progressive changes in adrenergic, serotonergic, and peptidergic nerves in proximal colon of streptozotocin-diabetic rats

A Belai, J Lincoln, P Milner, G Burnstock - Gastroenterology, 1988 - Elsevier
The effect of progression of diabetes on adrenergic, serotonergic, and peptidergic
innervation of the proximal colon of the rat at 8, 16, and 25 wk after induction of diabetes with …

Enteric nervous system: I. Physiology and pathophysiology of the intestinal tract

O Lundgren, J Svanvik, L Jivegård - Digestive diseases and sciences, 1989 - Springer
It is becoming increasingly evident that the nerves of mucosal surfaces may play an
important role both during physiological and pathophysiological circumstances. This has, of …