Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in
the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Glomerular hyperfiltration is a phenomenon that can occur in various clinical conditions
including kidney disease. No single definition of glomerular hyperfiltration has been agreed …

Background Renal function declines progressively in patients who have diabetic
nephropathy, and the decline may be slowed by antihypertensive drugs. The purpose of this …

The hyperfiltration theory: A paradigm shift in nephrology. Experimental studies incriminate
glomerular hypertension in mediating progressive renal damage after any of a variety of …

Diabetic nephropathy is a leading cause of end-stage renal failure worldwide. Its
morphologic characteristics include glomerular hypertrophy, basement membrane …

Emerging evidence suggests that transforming growth factor-β (TGF-β) is an important
mediator of diabetic nephropathy. We showed previously that short-term treatment with a …

Diabetes is now the most common cause of progressive kidney failure leading to dialysis or
transplantation. The central pathological feature of diabetic nephropathy is accumulation of …

Two groups of adult male Munich-Wistar rats and a third group of nondiabetic age-matched
and weight-matched normal control rats underwent micropuncture study 1 mo, and …

Nephropathy is a major complication of diabetes. Alterations of mesangial cells have
traditionally been the focus of research in deciphering molecular mechanisms of diabetic …