Genetics of circadian rhythms and sleep in human health and disease

JM Lane, J Qian, E Mignot, S Redline… - Nature Reviews …, 2023 - nature.com
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Circadian rhythm as a therapeutic target

W Ruan, X Yuan, HK Eltzschig - Nature Reviews Drug Discovery, 2021 - nature.com
The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Magnetic field effects in biology from the perspective of the radical pair mechanism

H Zadeh-Haghighi, C Simon - Journal of the Royal …, 2022 - royalsocietypublishing.org
Hundreds of studies have found that weak magnetic fields can significantly influence various
biological systems. However, the underlying mechanisms behind these phenomena remain …

Social jetlag and related risks for human health: a timely review

R Caliandro, AA Streng, LWM van Kerkhof… - Nutrients, 2021 - mdpi.com
The term social jetlag is used to describe the discrepancy between biological time,
determined by our internal body clock, and social times, mainly dictated by social obligations …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological Reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

SE Jones, JM Lane, AR Wood, VT van Hees… - Nature …, 2019 - nature.com
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

A Warnatsch, M Ioannou, Q Wang, V Papayannopoulos - Science, 2015 - science.org
Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of
pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of …

Genetics factors in major depression disease

M Shadrina, EA Bondarenko, PA Slominsky - Frontiers in psychiatry, 2018 - frontiersin.org
Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

KO Alfarouk, CM Stock, S Taylor, M Walsh… - Cancer cell …, 2015 - Springer
Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells
to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in …