On the dependency of cellular protein levels on mRNA abundance
The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …
importance for basic and translational life science research and has been studied by …
The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics
Skyline is a freely available, open‐source Windows client application for accelerating
targeted proteomics experimentation, with an emphasis on the proteomics and mass …
targeted proteomics experimentation, with an emphasis on the proteomics and mass …
Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system
Differential mRNA expression studies implicitly assume that changes in mRNA expression
have biological meaning, most likely mediated by corresponding changes in protein levels …
have biological meaning, most likely mediated by corresponding changes in protein levels …
Version 4.0 of PaxDb: protein abundance data, integrated across model organisms, tissues, and cell‐lines
M Wang, CJ Herrmann, M Simonovic… - …, 2015 - Wiley Online Library
Protein quantification at proteome‐wide scale is an important aim, enabling insights into
fundamental cellular biology and serving to constrain experiments and theoretical models …
fundamental cellular biology and serving to constrain experiments and theoretical models …
Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
C Vogel, EM Marcotte - Nature reviews genetics, 2012 - nature.com
Recent advances in next-generation DNA sequencing and proteomics provide an
unprecedented ability to survey mRNA and protein abundances. Such proteome-wide …
unprecedented ability to survey mRNA and protein abundances. Such proteome-wide …
Phenotypic impact of genomic structural variation: insights from and for human disease
J Weischenfeldt, O Symmons, F Spitz… - Nature Reviews …, 2013 - nature.com
Genomic structural variants have long been implicated in phenotypic diversity and human
disease, but dissecting the mechanisms by which they exert their functional impact has …
disease, but dissecting the mechanisms by which they exert their functional impact has …
Synonymous but not the same: the causes and consequences of codon bias
JB Plotkin, G Kudla - Nature Reviews Genetics, 2011 - nature.com
Despite their name, synonymous mutations have significant consequences for cellular
processes in all taxa. As a result, an understanding of codon bias is central to fields as …
processes in all taxa. As a result, an understanding of codon bias is central to fields as …
The quantitative proteome of a human cell line
The generation of mathematical models of biological processes, the simulation of these
processes under different conditions, and the comparison and integration of multiple data …
processes under different conditions, and the comparison and integration of multiple data …
Global signatures of protein and mRNA expression levels
Cellular states are determined by differential expression of the cell's proteins. The
relationship between protein and mRNA expression levels informs about the combined …
relationship between protein and mRNA expression levels informs about the combined …