The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

The epidermis is a living, multilayered barrier with five functional levels, including a physical,
a chemical, a microbial, a neuronal, and an immune level. Altogether, this complex organ …

Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

Background There is currently no insight into biomarkers that can predict the onset of
pediatric atopic dermatitis (AD). Methods Nested in a prospective birth cohort study that …

Mouse models for atopic dermatitis (AD) are an indispensable preclinical research tool for
testing new candidate AD therapeutics and for interrogating AD pathobiology in vivo. In this …

Dysfunction of the skin barrier plays a critical role in the initiation and progression of
inflammatory skin diseases, such as atopic dermatitis and contact dermatitis. Epidermal …

Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease in which dry and
itchy skin may develop into skin lesions. AD has a strong genetic component, as children …

Background This study aimed to evaluate the safety of applying zinc oxide nanoparticles
(ZnO NPs) to pathological skin. The majority of previous studies confirmed the safety of …

Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children
and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which …

Bleomycin hydrolase (BLMH) is a well-conserved cysteine protease widely expressed in
several mammalian tissues. In skin, which contains high levels of BLMH, this protease is …