The preparation of urea by Wöhler constituted a landmark achievement in organic chemistry,
and it laid the ground for the early days of target-oriented organic synthesis. 1 Since then …

Quaternary stereocenters are a particular challenge for stereoselective synthesis. With a
central view on this specific structural issue, selected examples from the recent literature are …

A Ni-catalyzed enantioselective reductive three-component alkylalkenylation of β, γ-alkenyl
ketones with cis-alkenyl iodides and fluoroalkyl iodides in the presence of Mn is reported. By …

An unprecedented α‐allylation of amines was achieved by combining palladium catalysis
and visible‐light photoredox catalysis. In this dual catalysis process, the catalytic generation …

Over the past few years, iridium complexes have been widely used in the direct
functionalization of unactivated bonds. In the presence of iridium catalysts, inactive C–H and …

This book provides a noteworthy compilation of the groundbreaking methods of
stereoselective synthesis, belonging to the repertoire of every modern practitioner of …

All‐carbon quaternary stereocenters have posed significant challenges in the synthesis of
complex natural products. These important structural motifs have inspired the development …

The ability to control the alkylation of organic substrates becomes ever more powerful by
using metal catalysts. Among the major benefits of metal catalysis is the possibility to …

Ir-Catalysed allylic substitution is supplementing the traditional Pd-catalysed variant. With
simple, easily available monosubstituted allylic acetates and carbonates as substrates, Ir …

Abstract α‐Quaternary ketones are accessed through novel enantioselective alkylations of
allyl and propargyl electrophiles by unstabilized prochiral enolate nucleophiles in the …