Arthritogenic alphavirus-induced immunopathology and targeting host inflammation as a therapeutic strategy for alphaviral disease

H Mostafavi, E Abeyratne, A Zaid, A Taylor - Viruses, 2019 - mdpi.com
Arthritogenic alphaviruses are a group of medically important arboviruses that cause
inflammatory musculoskeletal disease in humans with debilitating symptoms, such as …

Cytokines and chemokines in chikungunya virus infection: protection or induction of pathology

C Chirathaworn, J Chansaenroj, Y Poovorawan - Pathogens, 2020 - mdpi.com
Chikungunya virus (CHIKV) infection has been commonly detected in tropical countries. The
clinical manifestations of CHIKV infection are similar to those of rheumatoid arthritis …

[PDF][PDF] Post COVID inflammation syndrome: different manifestations caused by the virus

SF Nizar, D Kori - Journal of the Association of Physicians of India, 2020 - researchgate.net
Background: Incidence of viral pneumonia has been reported in several patients diagnosed
with COVID-19. The infection has also been linked to the development of inflammatory …

Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms

SR Tritsch, L Encinales, N Pacheco, A Cadena… - The Journal of …, 2020 - jrheum.org
Objective. To determine the frequency of chronic joint pain and stiffness 3 years after
infection with chikungunya virus (CHIKV) in a Latin American cohort. Methods. A cross …

Attenuation of neurovirulence of chikungunya virus by a single amino acid mutation in viral E2 envelope protein

H Chen, P Phuektes, LS Yeo, YH Wong… - Journal of Biomedical …, 2024 - Springer
Background Chikungunya virus (CHIKV) has reemerged as a major public health concern,
causing chikungunya fever with increasing cases and neurological complications. Methods …

Pathogenicity and virulence of chikungunya virus

W Freppel, LA Silva, KA Stapleford, LJ Herrero - Virulence, 2024 - Taylor & Francis
Chikungunya virus (CHIKV) is a mosquito-transmitted, RNA virus that causes an often-
severe musculoskeletal illness characterized by fever, joint pain, and a range of debilitating …

Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updates

I Guerrero-Arguero… - Journal of General …, 2021 - microbiologyresearch.org
Human pathogens belonging to the Alphavirus genus, in the Togaviridae family, are
transmitted primarily by mosquitoes. The signs and symptoms associated with these viruses …

Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines

AL Sandenon Seteyen, E Girard-Valenciennes… - Molecules, 2022 - mdpi.com
The discovery and the development of safe and efficient therapeutics against arthritogenic
alphaviruses (eg, chikungunya virus) remain a continuous challenge. Alkaloids are …

Telmisartan Restricts Chikungunya Virus Infection In Vitro and In Vivo through the AT1/PPAR-γ/MAPKs Pathways

S De, P Mamidi, S Ghosh, SS Keshry… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Chikungunya virus (CHIKV) has reemerged as a global public health threat. The
inflammatory pathways of the renin-angiotensin system (RAS) and peroxisome proliferator …

IL-27 in patients with Chikungunya fever: A possible chronicity biomarker?

NG Cavalcanti, K MeloVilar, ALBP Duarte… - Acta tropica, 2019 - Elsevier
Background/purpose Although many patients with chikungunya virus disease (CHIKVD), an
arboviral disease characterized by sudden fever and incapacitating poliartralgia, develop …