Objectives Platinum-based chemotherapies are currently the first-line treatment of non-small
cell lung cancer. This study will improve our understanding of the causes of resistance to …

DNA methylation plays a critical role in gene regulation by modulating the DNA binding of
transcription factors (TFs). This study integrates TFs' ChIP-seq profiles with WGBS profiles to …

Careful microscopic observation of histopathological specimens, accumulation of large
numbers of high‐quality tissue specimens, and analysis of molecular pathology in relation to …

ABSTRACT DNA methylation on CpGs regulates transcription in mammals, both by
decreasing the binding of methylation-repelled factors and by increasing the binding of …

The protein interactome of p65/RELA, the most active subunit of the transcription factor (TF)
NF-κB, has not been previously determined in living cells. Using p65-miniTurbo fusion …

The ubiquitin proteasome system regulates key cellular processes in normal and in cancer
cells. Herein, we review published data on the role of ubiquitin ligases in the four major …

Background Liver fibrosis is a major risk factor for hepatocellular carcinoma (HCC). We have
previously reported that differentially methylated regions (DMRs) are correlated with the …

Objective The aim of this study was to establish criteria that would indicate whether fertility
preservation therapy would likely be safe for patients aged 40 years or less with …

Pathological low birth weight due to fetal growth restriction (FGR) is an important predictor of
adverse obstetric and neonatal outcomes. It is more common amongst native lowlanders …

Members of the broad complex, tram track, bric-a-brac and zinc finger (BTB-ZF) family of
transcription factors, such as BCL-6, ZBTB20, and ZBTB32, regulate antigen-specific B cell …