What drives osteoarthritis?—synovial versus subchondral bone pathology

T Hügle, J Geurts - Rheumatology, 2017 - academic.oup.com
Subchondral bone and the synovium play an important role in the initiation and progression
of OA. MRI often permits an early detection of synovial hypertrophy and bone marrow …

On the predictive utility of animal models of osteoarthritis

AM Malfait, CB Little - Arthritis research & therapy, 2015 - Springer
Animal models of osteoarthritis are extensively used for investigating disease pathways and
for preclinical testing of novel therapies. Their predictive utility, however, has often been …

Ball‐bearing‐inspired polyampholyte‐modified microspheres as bio‐lubricants attenuate osteoarthritis

J Yang, Y Han, J Lin, Y Zhu, F Wang, L Deng, H Zhang… - Small, 2020 - Wiley Online Library
Osteoarthritis, a lubrication dysfunction related disorder in joint, is characterized by articular
cartilage degradation and joint capsule inflammation. Enhancing joint lubrication, combined …

Artemisinin relieves osteoarthritis by activating mitochondrial autophagy through reducing TNFSF11 expression and inhibiting PI3K/AKT/mTOR signaling in cartilage

J Li, M Jiang, Z Yu, C Xiong, J Pan, Z Cai, N Xu… - Cellular & molecular …, 2022 - Springer
Osteoarthritis (OA) is a widespread chronic degenerative joint disease characterized by the
degeneration of articular cartilage or inflamed joints. Our findings indicated that treatment …

Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis

S Zhao, G Xiu, J Wang, Y Wen, J Lu, B Wu… - Journal of …, 2023 - Springer
Osteoarthritis (OA) is a degenerative joint disease involving cartilage. Exosomes derived
from Mesenchymal stem cells (MSCs) therapy improves articular cartilage repair, but …

Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis

H Chen, T Sun, Y Yan, X Ji, Y Sun, X Zhao, J Qi, W Cui… - Biomaterials, 2020 - Elsevier
The superlubrication of natural joint has been attributed to hydration lubrication of articular
cartilage. Here, inspired by the structure of phosphatidylcholine lipid (a typical cartilage …

Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis

N Das, LGN de Almeida, A Derakhshani… - Nature …, 2023 - nature.com
PRG4 is an extracellular matrix protein that maintains homeostasis through its boundary
lubricating and anti-inflammatory properties. Altered expression and function of PRG4 have …

Euryale Ferox Seed‐Inspired Superlubricated Nanoparticles for Treatment of Osteoarthritis

Y Yan, T Sun, H Zhang, X Ji, Y Sun… - Advanced Functional …, 2019 - Wiley Online Library
Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease,
which is characterized by the breakdown of articular cartilage at the joint surface and the …

Microfluidics‐assisted assembly of injectable photonic hydrogels toward reflective cooling

Z Zhu, JD Liu, C Liu, X Wu, Q Li, S Chen, X Zhao… - Small, 2020 - Wiley Online Library
Abstract Development of fast curing and easy modeling of colloidal photonic crystals is
highly desirable for various applications. Here, a novel type of injectable photonic hydrogel …

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways

J Ran, C Ma, K Xu, L Xu, Y He… - Drug design …, 2018 - Taylor & Francis
Introduction Osteoarthritis (OA) is the most prevalent joint disorder in the elderly population,
and inflammatory mediators like IL-1β were thought to play central roles in its development …