Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors

DC Metz, RT Jensen - Gastroenterology, 2008 - Elsevier
Pancreatic endocrine tumors (PETs) have long fascinated clinicians and investigators
despite their relative rarity. Their clinical presentation varies depending on whether the …

Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies

RT Jensen, MJ Berna, DB Bingham, JA Norton - Cancer, 2008 - Wiley Online Library
Pancreatic endocrine tumors (PETs) have long fascinated clini-cians, because some can
release biologically active hormones that cause distinct syndromes and provide important …

Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway

E Missiaglia, I Dalai, S Barbi, S Beghelli… - Journal of clinical …, 2010 - ascopubs.org
Purpose We investigated the global gene expression in a large panel of pancreatic
endocrine tumors (PETs) aimed at identifying new potential targets for therapy and …

The identification of gut neuroendocrine tumor disease by multiple synchronous transcript analysis in blood

IM Modlin, I Drozdov, M Kidd - PloS one, 2013 - journals.plos.org
Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are increasing in both
incidence and prevalence. A delay in correct diagnosis is common for these lesions. This …

Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis

A Arlt, H Schäfer - European journal of cell biology, 2011 - Elsevier
The expression of the early response gene immediate early response 3 (IER3), formerly
known as IEX-1, is induced by a great variety of stimuli, such as growth factors, cytokines …

Gene expression patterns in pancreatic tumors, cells and tissues

AW Lowe, M Olsen, Y Hao, SP Lee, K Taek Lee… - PloS one, 2007 - journals.plos.org
Background Cancers of the pancreas originate from both the endocrine and exocrine
elements of the organ, and represent a major cause of cancer-related death. This study …

New insights into the structure and mechanism of iodothyronine deiodinases

U Schweizer, C Steegborn - Journal of molecular …, 2015 - jme.bioscientifica.com
Pancreatic neuroendocrine tumours (PETs) are the second most frequent pancreatic
neoplasms. Their poor chemosensitivity, high rate of metastatic disease and relatively long …

Towards a new classification of gastroenteropancreatic neuroendocrine neoplasms

M Kidd, I Modlin, K Öberg - Nature reviews Clinical oncology, 2016 - nature.com
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) constitute a
heterogeneous group of tumours associated with variable clinical presentations, growth …

Gene expression profiles of progressive pancreatic endocrine tumours and their liver metastases reveal potential novel markers and therapeutic targets

G Capurso, S Lattimore… - Endocrine-related …, 2006 - erc.bioscientifica.com
The intrinsic nature of tumour behaviour (stable vs progressive) and the presence of liver
metastases are key factors in determining the outcome of patients with a pancreatic …

Molecular genetics of neuroendocrine tumors

EM Duerr, DC Chung - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier
Neuroendocrine tumors can develop either sporadically or in association with familial
syndromes such as multiple endocrine neoplasia type 1 (MEN1), multiple endocrine …