The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis
A Shilatifard - Annual review of biochemistry, 2012 - annualreviews.org
The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …
methylase identified over 10 years ago. Since then, it has been demonstrated that …
Cigarette smoking and DNA methylation
KWK Lee, Z Pausova - Frontiers in genetics, 2013 - frontiersin.org
DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
Single-cell RNA-seq reveals lineage and X chromosome dynamics in human preimplantation embryos
Mouse studies have been instrumental in forming our current understanding of early cell-
lineage decisions; however, similar insights into the early human development are severely …
lineage decisions; however, similar insights into the early human development are severely …
linking metabolism to epigenetics through O-GlcNAcylation
JA Hanover, MW Krause, DC Love - Nature reviews Molecular cell …, 2012 - nature.com
O-GlcNAcylation, which is a nutrient-sensitive sugar modification, participates in the
epigenetic regulation of gene expression. The enzymes involved in O-linked β-dN …
epigenetic regulation of gene expression. The enzymes involved in O-linked β-dN …
X chromosome regulation: diverse patterns in development, tissues and disease
X Deng, JB Berletch, DK Nguyen… - Nature Reviews …, 2014 - nature.com
Genes on the mammalian X chromosome are present in one copy in males and two copies
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …
in females. The complex mechanisms that regulate the X chromosome lead to evolutionary …
The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation
Background In mammals, X chromosome genes are present in one copy in males and two in
females. To balance the dosage of X-linked gene expression between the sexes, one of the …
females. To balance the dosage of X-linked gene expression between the sexes, one of the …
[HTML][HTML] Jarid2 is implicated in the initial Xist-induced targeting of PRC2 to the inactive X chromosome
ST da Rocha, V Boeva, M Escamilla-Del-Arenal… - Molecular cell, 2014 - cell.com
During X chromosome inactivation (XCI), the Polycomb Repressive Complex 2 (PRC2) is
thought to participate in the early maintenance of the inactive state. Although Xist RNA is …
thought to participate in the early maintenance of the inactive state. Although Xist RNA is …
Evolution of vertebrate sex chromosomes and dosage compensation
JAM Graves - Nature Reviews Genetics, 2016 - nature.com
Differentiated sex chromosomes in mammals and other vertebrates evolved independently
but in strikingly similar ways. Vertebrates with differentiated sex chromosomes share the …
but in strikingly similar ways. Vertebrates with differentiated sex chromosomes share the …
The role of Xist‐mediated Polycomb recruitment in the initiation of X‐chromosome inactivation
Xist RNA has been established as the master regulator of X‐chromosome inactivation (XCI)
in female eutherian mammals, but its mechanism of action remains unclear. By creating …
in female eutherian mammals, but its mechanism of action remains unclear. By creating …
[HTML][HTML] DNA modifications: function and applications in normal and disease States
VRB Liyanage, JS Jarmasz, N Murugeshan… - Biology, 2014 - mdpi.com
Epigenetics refers to a variety of processes that have heritable effects on gene expression
programs without changes in DNA sequence. Key players in epigenetic control are chemical …
programs without changes in DNA sequence. Key players in epigenetic control are chemical …