Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

L Cheng, J Wang, H Dai, Y Duan, Y An, L Shi, Y Lv… - Adipocyte, 2021 - Taylor & Francis
Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

Noncoding RNAs in gastric cancer: implications for drug resistance

L Wei, J Sun, N Zhang, Y Zheng, X Wang, L Lv, J Liu… - Molecular cancer, 2020 - Springer
Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-
related deaths worldwide. Advanced gastric cancer patients can notably benefit from …

Delivery of oligonucleotide therapeutics: chemical modifications, lipid nanoparticles, and extracellular vesicles

JP Bost, H Barriga, MN Holme, A Gallud, M Maugeri… - ACS …, 2021 - ACS Publications
Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …

Global positioning system: understanding long noncoding RNAs through subcellular localization

J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …

miRTarBase update 2022: an informative resource for experimentally validated miRNA–target interactions

HY Huang, YCD Lin, S Cui, Y Huang… - Nucleic acids …, 2022 - academic.oup.com
MicroRNAs (miRNAs) are noncoding RNAs with 18–26 nucleotides; they pair with target
mRNAs to regulate gene expression and produce significant changes in various …

[HTML][HTML] Mir-21 promotes cardiac fibrosis after myocardial infarction via targeting Smad7

J Yuan, H Chen, D Ge, Y Xu, H Xu, Y Yang… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Cardiac fibrosis after myocardial infarction (MI) has been identified as an
important factor in the deterioration of heart function. Previous studies have demonstrated …

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

CF Zhou, J Ma, L Huang, HY Yi, YM Zhang, XG Wu… - Oncogene, 2019 - nature.com
Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in
the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma …

NLRP3 inflammasome at the interface of inflammation, endothelial dysfunction, and type 2 diabetes

IM Gora, A Ciechanowska, P Ladyzynski - Cells, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Long noncoding RNAs: Novel insights into hepatocelluar carcinoma

Y He, XM Meng, C Huang, BM Wu, L Zhang, XW Lv… - Cancer letters, 2014 - Elsevier
Recent advances in non-protein coding part of human genome analysis have discovered
extensive transcription of large RNA transcripts that lack of coding protein function, termed …

Diabetes as a risk factor for periodontal disease—plausible mechanisms

D Polak, T Sanui, F Nishimura… - Periodontology 2000, 2020 - Wiley Online Library
The present narrative review examines the scientific evidence of the biological mechanisms
that may link periodontitis and diabetes, as a source of comorbidity. Publications regarding …