Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

It was suggested that vitamin D levels influence cancer development. The vitamin D receptor
(VDR) is a crucial mediator for the cellular effects of vitamin D. Results from previous studies …

Vitamin D, a fat-soluble prohormone, is synthesised in response to sunlight. Vitamin D
requires two metabolic conversions, 25-hydroxylation in the liver and 1a-hydroxylation in the …

Background Breast cancer is a heterogeneous disease associated with different patient
prognosis and responses to therapy. Vitamin D has been emerging as a potential treatment …

Abstract KDM6B/JMJD3 is a histone H3 lysine demethylase with an important gene
regulatory role in development and physiology. Here, we show that human JMJD3 …

Vitamin D has important benefits in reducing the risk of many conditions and diseases.
Those diseases for which the benefits are well supported and that have large economic …

Results: During 6.5 years of follow-up, 228 (22.7%) participants died, of whom 107 died due
to cardiovascular diseases. Compared with participants in the highest quartile of serum 25 …

The most active vitamin D metabolite, 1α, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3), is a
pleiotropic hormone with wide regulatory actions. Classically, vitamin D deficiency was …

Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through
genomic effects modulated by the vitamin D receptor (VDR), and autocrine/paracrine …

Vitamin D deficiency is linked to pathogenesis of many diseases including cardiovascular,
cancer, and various eye diseases. In recent years, important roles for vitamin D in regulation …