Gout is an autoinflammatory disease caused by the deposition of urate crystals. As the most
common inflammatory arthritis, gout has a high incidence and can induce various severe …

Gout is characterized by hyperuricemia and the deposition of monosodium urate (MSU)
crystals around joints. Despite the availability of several drugs on the market, its treatment …

Endothelial cells (ECs) normally form an anticoagulant surface under physiological
conditions, but switch to support coagulation following pathogenic stimuli. This switch …

Hyperuricemia is a critical threat to human health, and conventional medical treatment only
aims to treat acute gouty arthritis. Purine diet-mediated chronic hyperuricemia and related …

Urate homeostasis in humans is a complex and highly heritable process that involves ie,
metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate …

Numerous studies have demonstrated that gut microbiota is essential for the host's health
because it regulates the host's metabolism, endocrine, and immune systems. In recent …

High serum urate levels are the major risk factor for gout. URAT1, the primary transporter for
urate absorption in the kidneys, is well known as an anti-hyperuricemia drug target …

Objective The predominant mechanism driving hyperuricemia in gout is renal uric acid
underexcretion; however, the standard urate‐lowering therapy (ULT) recommendation is first …

The design of novel validated methodologies targeting many goals such as simplicity,
greenness, analytical efficiency and sustainability, has gained great concern in quality …

Hyperuricemia with consequent monosodium urate crystal deposition leads to gout,
characterized by painful, incapacitating inflammatory arthritis flares that are also associated …