Targeted and multifunctional arene ruthenium chemotherapeutics

GS Smith, B Therrien - Dalton transactions, 2011 - pubs.rsc.org
The introduction of multifunctionalities for tumour targeting is becoming a popular strategy
toward the development of new therapeutic agents. In particular, the multifaceted potential of …

Functionalised η6-arene ruthenium complexes

B Therrien - Coordination Chemistry Reviews, 2009 - Elsevier
η6-Arene ruthenium complexes have been known for more than 30 years, and their
chemistry has been extensively studied for unfunctionalised arenes such as benzene, para …

Visible‐light‐induced annihilation of tumor cells with platinum–porphyrin conjugates

A Naik, R Rubbiani, G Gasser… - Angewandte Chemie, 2014 - Wiley Online Library
Despite the extensive use of porphyrins in photodynamic therapy (PDT), tetraplatinated
porphyrins have so far not been studied for their anticancer properties. Herein, we report the …

Ruthenium porphyrin compounds for photodynamic therapy of cancer

F Schmitt, P Govindaswamy, G Süss-Fink… - Journal of medicinal …, 2008 - ACS Publications
Five 5, 10, 15, 20-tetra (4-pyridyl) porphyrin (TPP) areneruthenium (II) derivatives and ap-
cymeneosmium and two pentamethylcyclopentadienyliridium and-rhodium analogues were …

Modifications of porphyrins and hydroporphyrins for their solubilization in aqueous media

M Luciano, C Brückner - Molecules, 2017 - mdpi.com
The increasing popularity of porphyrins and hydroporphyrins for use in a variety of
biomedical (photodynamic therapy, fluorescence tagging and imaging, photoacoustic …

Ruthenium− porphyrin conjugates with cytotoxic and phototoxic antitumor activity

T Gianferrara, A Bergamo, I Bratsos… - Journal of medicinal …, 2010 - ACS Publications
We report here two novel “extended-arms” porphyrins, TetbpyPP and TedabpyPP, in which
four peripheral bpy fragments are connected to the meso positions of the macrocycle …

Peripherally metalated porphyrins with applications in catalysis, molecular electronics and biomedicine

JF Longevial, S Clément, JA Wytko… - … A European Journal, 2018 - Wiley Online Library
Porphyrins are conjugated, stable chromophores with a central core that binds a variety of
metal ions and an easily functionalized peripheral framework. By combining the catalytic …

Synthetic strategies and structural aspects of metal-mediated multiporphyrin assemblies

E Iengo, E Zangrando, E Alessio - Accounts of chemical research, 2006 - ACS Publications
Porphyrins play a major role as active chromophores in artificial systems mimicking the
natural photoinduced processes. The formation of coordination bonds between peripheral …

A fluorinated ruthenium porphyrin as a potential photodynamic therapy agent: synthesis, characterization, DNA binding, and melanoma cell studies

S Rani-Beeram, K Meyer, A McCrate, Y Hong… - Inorganic …, 2008 - ACS Publications
When the new porphyrin 5, 10-(4-pyridyl)-15, 20-(pentafluorophenyl) porphyrin is reacted
with 2 equiv of Ru (bipy) 2Cl2 (where bipy= 2, 2′-bipyridine) formation of the target …

[HTML][HTML] Systems biology approach for in vivo photodynamic therapy optimization of ruthenium-porphyrin compounds

M Pernot, T Bastogne, NPE Barry, B Therrien… - … of Photochemistry and …, 2012 - Elsevier
Two arene ruthenium porphyrin compounds showing interesting photodynamic activity in
vitro,[Ru (η6-p-PriC6H4Me)(PMP) Cl2](PMP= 5-(3-pyridyl)-10, 15, 20-triphenylporphyrin) …