[HTML][HTML] Painful intervertebral disc degeneration and inflammation: from laboratory evidence to clinical interventions

FJ Lyu, H Cui, H Pan, K Mc Cheung, X Cao, JC Iatridis… - Bone research, 2021 - nature.com
Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

The involvement of immune system in intervertebral disc herniation and degeneration

F Ye, FJ Lyu, H Wang, Z Zheng - JOR spine, 2022 - Wiley Online Library
Intervertebral disc (IVD) herniation and degeneration contributes significantly to low back
pain (LBP), of which the molecular pathogenesis is not fully understood. Disc herniation may …

Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis

LF O'Mahony, A Srivastava, P Mehta, C Ciurtin - Rheumatology, 2021 - academic.oup.com
Objectives The aetiology of primary chronic pain syndromes (CPS) is highly disputed. We
performed a systematic review and meta-analysis aiming to assess differences in circulating …

[HTML][HTML] The role of structure and function changes of sensory nervous system in intervertebral disc-related low back pain

S Zhang, B Hu, W Liu, P Wang, X Lv, S Chen… - Osteoarthritis and …, 2021 - Elsevier
Low back pain (LBP) is a common musculoskeletal symptom, which can be developed in
multiple clinical diseases. It is widely recognized that intervertebral disc (IVD) degeneration …

[HTML][HTML] Neuraxial cytokines in pain states

G Gonçalves dos Santos, L Delay, TL Yaksh… - Frontiers in …, 2020 - frontiersin.org
A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

Mesenchymal stem cells-derived exosomes ameliorate nucleus pulposus cells apoptosis via delivering miR-142-3p: therapeutic potential for intervertebral disc …

L Zhu, Y Shi, L Liu, H Wang, P Shen, H Yang - Cell cycle, 2020 - Taylor & Francis
Intervertebral disc degeneration (IDD) is the main cause of lower back pain (LBP), and
puzzles massive individuals worldwide. Mesenchymal stem cells (MSCs) transplantation …

[HTML][HTML] Macrophages and intervertebral disc degeneration

J Koroth, EO Buko, R Abbott, CP Johnson… - International journal of …, 2023 - mdpi.com
The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the
spine. With little inherent regenerative capacity, degeneration of the intervertebral disc …

[HTML][HTML] Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration

Y Peng, X Qing, H Shu, S Tian, W Yang… - Biomaterials …, 2021 - ncbi.nlm.nih.gov
Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …

How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies

YL Lima, H Lee, DM Klyne, FL Dobson… - Arthritis Care & …, 2023 - Wiley Online Library
Objective Nonsurgical interventions are recommended for osteoarthritis (OA). However, how
interventions change pain and physical function is unclear. Therefore, the objectives of this …

Personalized assessment and management of non‐specific low back pain

B Wirth, P Schweinhardt - European Journal of Pain, 2024 - Wiley Online Library
Abstract Background and Objective Low back pain (LBP), and in particular non‐specific low
back pain (NSLBP), which accounts for approximately 90% of LBP, is the leading cause of …